OpenDose

OpenDose is a collaboration of about 18 international research teams that produces and shares specific absorbed fractions (SAFs) and S values for internal dosimetry, calculated with six Monte Carlo radiation-transport codes (EGSnrc/EGS++, FLUKA, GATE, Geant4, MCNP/MCNPX and PENELOPE) run in parallel so results can be cross-checked. Data are generated for the source/target region combinations of the ICRP Publication 110 adult reference phantoms (male and female), with radionuclide decay data taken from ICRP Publication 107, and are stored in a relational database with their statistical uncertainties for traceability.

The website displays interactive plots of S values for 1,252 radionuclides and lets users download the underlying data as CSV. As of the project's 2020 description it held over 11 million SAF entries spanning 2 phantom models, 141 source regions, 172 target regions and 91 energies. The collaboration also aims to extend the work to voxel-based (patient-specific) dosimetry models and to publish software and educational material alongside the data.

For a radiopharmaceutical record in this graph, OpenDose is most useful as the traceable source of the physical dosimetry inputs (S values, SAFs) that feed patient dose calculations for isotopes such as lutetium-177 or actinium-225, complementing but not replacing clinical dosimetry guidelines.