{"entity":{"id":"opendose","kind":"collection","name":"OpenDose","aka":[],"tldr":"A free online resource that lets nuclear medicine physicists look up how much radiation dose different organs receive from radioactive drugs, instead of everyone recalculating it from scratch.","summary":"OpenDose is a collaboration of about 18 international research teams that produces and shares specific absorbed fractions (SAFs) and S values for internal dosimetry, calculated with six Monte Carlo radiation-transport codes (EGSnrc/EGS++, FLUKA, GATE, Geant4, MCNP/MCNPX and PENELOPE) run in parallel so results can be cross-checked. Data are generated for the source/target region combinations of the ICRP Publication 110 adult reference phantoms (male and female), with radionuclide decay data taken from ICRP Publication 107, and are stored in a relational database with their statistical uncertainties for traceability.\n\nThe website displays interactive plots of S values for 1,252 radionuclides and lets users download the underlying data as CSV. As of the project's 2020 description it held over 11 million SAF entries spanning 2 phantom models, 141 source regions, 172 target regions and 91 energies. The collaboration also aims to extend the work to voxel-based (patient-specific) dosimetry models and to publish software and educational material alongside the data.\n\nFor a radiopharmaceutical record in this graph, OpenDose is most useful as the traceable source of the physical dosimetry inputs (S values, SAFs) that feed patient dose calculations for isotopes such as lutetium-177 or actinium-225, complementing but not replacing clinical dosimetry guidelines.","asOf":"2026-09-22","links":[{"label":"OpenDose project mirror","url":"https://opendose.polsl.pl/project/"},{"label":"OpenDose S values tool","url":"https://opendose.polsl.pl/svalues/"},{"label":"Chauvin et al., J Nucl Med 2020: OpenDose: Open-Access Resource for Nuclear Medicine Dosimetry","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7539649/"}],"tags":["dosimetry","open data","physics"],"related":["lu-177","ac-225"],"indications":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["dosimetry"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"url":"https://opendose.polsl.pl/project/","holds":"Specific absorbed fractions (SAFs) and S values for internal dosimetry across 1,252 radionuclides, computed with six Monte Carlo codes on the ICRP 110 adult reference phantoms; downloadable as CSV, with a bibliography and lecture material.","license":"Free public access for viewing and CSV download; the collaboration is open to new contributing research teams. No formal open-data licence is stated on the site.","maintainer":"OpenDose collaboration, an international network of academic nuclear medicine physics groups (coordination includes INSERM, Toulouse); mirrored by Politechnika Śląska (Silesian University of Technology, Poland)."},"route":"/collections/opendose/","neighbours":{"isotope":[{"id":"ac-225","kind":"isotope","name":"Actinium-225","route":"/isotopes/ac-225/"},{"id":"lu-177","kind":"isotope","name":"Lutetium-177","route":"/isotopes/lu-177/"}],"term":[{"id":"dosimetry","kind":"term","name":"Dosimetry","route":"/terms/dosimetry/"}],"collection":[{"id":"icrp-publications","kind":"collection","name":"ICRP publications and dose coefficient databases","route":"/collections/icrp-publications/"}]}}