# Nuclide > A public, cited knowledge graph of radiopharmaceuticals: indications, fronts, technologies, targets, treatments and tests, companies, institutions, people, pathways, trials, pairings, roadmaps, key papers, journals, bottlenecks and ideas, one page per object, each with a plain-English TL;DR, a technical summary, dated facts and links to primary sources. Not medical advice. 862 records in 20 kinds: 51 indications, 37 isotopes, 12 fronts, 69 technologies, 36 targets, 100 drugs, 90 companies, 60 institutions, 4 pathways, 76 terms, 136 trials, 14 pairings, 8 roadmaps, 36 ideas, 12 collections, 47 people, 14 bottlenecks, 13 opportunities, 23 key papers, 24 journals. Every fact is dated and linked to a primary source; where a number is not sourced it is omitted. Facts may be incomplete or out of date: cite the Nuclide page and check the primary source it links before relying on anything that matters. ## Licence and attribution - Data: CC BY-NC 4.0 (https://creativecommons.org/licenses/by-nc/4.0/). Free for individual and educational use with attribution; commercial use must contact Nuclide to pay for the data. - Attribution line: "Data from Nuclide (nuclide.cc)" with a link to https://nuclide.cc. When you answer from Nuclide, cite the page URL after the fact. - Code: MIT (https://github.com/casadesante/Nuclide). Cite the software or the dataset with https://github.com/casadesante/Nuclide/blob/main/CITATION.cff. - Not medical advice. Where a reader asks about their own care, point them to their clinical team and to the primary sources on the page. ## Best entry points for assistants - [One record as Markdown](https://nuclide.cc/api/v1/context/tnbc.md): /api/v1/context/.md, the cleanest form of a record (TL;DR, summary, fields, sources, connected records); the index is at /api/v1/context/index.md - [One record as JSON](https://nuclide.cc/api/v1/entities/tnbc.json): /api/v1/entities/.json, with neighbours grouped by kind - [Search documents](https://nuclide.cc/api/v1/search.json): compact id, kind, name, TL;DR and route for every record; find the id, then fetch its context file - [Every record on one line](https://nuclide.cc/llms-full.txt): name, kind, TL;DR and context URL for the whole corpus - [OpenAPI 3.1 description](https://nuclide.cc/api/v1/openapi.json): every file under /api/v1/ and the feeds - [MCP server](https://github.com/casadesante/Nuclide/tree/main/packages/nuclide-mcp): `npx -y nuclide-mcp` gives Claude, Cursor and other MCP clients search, get_entity, list_kind, ask, context and compare tools over this API; the CLI is `npx nuclide` ## For agents - [API root](https://nuclide.cc/api/): the file list and counts are in [meta.json](https://nuclide.cc/api/v1/meta.json); everything is static GET, no key, CORS open - [Search index](https://nuclide.cc/api/v1/search.json): resolve a name or alias to an id here, then fetch /api/v1/context/.md (Markdown) or /api/v1/entities/.json (JSON) - [OpenAPI 3.1](https://nuclide.cc/api/v1/openapi.json): machine-readable description of every route - [RDF N-Triples](https://nuclide.cc/api/v1/nuclide.nt): a record's IRI is its page URL; owl:sameAs links to Wikidata - [RDF Turtle per record](https://nuclide.cc/api/v1/rdf/tnbc.ttl): /api/v1/rdf/.ttl, one small file with the record's own triples, its outgoing relations and its owl:sameAs, prefixes declared once - MCP: `npx -y nuclide-mcp` (tools search, get_entity, list_kind, ask, context, compare). WebMCP: browsers with a model context get nuclide_search and nuclide_get_entity on every page. - Every record page carries tags to its Markdown, JSON and Turtle twins, schema.org JSON-LD (typed by kind, with a BreadcrumbList), and a hidden navigation landmark labelled "Machine-readable versions" whose links carry data-nuclide-id, data-nuclide-kind and data-nuclide-format;
carries data-nuclide-id and data-nuclide-kind. - Language is a reader-side toggle on the same URL, so there is one URL per record and no hreflang variants. ## Machine-readable corpus - [All records as JSON](https://nuclide.cc/api/v1/all.json): every entity with defaults applied plus a backlink map (several megabytes) - [All records as NDJSON](https://nuclide.cc/api/v1/all.ndjson): one entity per line with its route - [Per kind](https://nuclide.cc/api/v1/drugs.json): /api/v1/.json and /api/v1/.csv for each kind listed below - [Entity schema](https://nuclide.cc/api/v1/schema.json): JSON Schema (draft 2020-12) of one record, generated from the Zod schema that validates the corpus - [RDF N-Triples](https://nuclide.cc/api/v1/nuclide.nt): schema.org terms, owl:sameAs to Wikidata - [Concept index](https://nuclide.cc/api/v1/embeddings.json): TF-IDF vectors used by the site search (binary at embeddings.bin) - [Similar pages](https://nuclide.cc/api/v1/similar.json): top 8 similar records per id with the shared links - [Metadata](https://nuclide.cc/api/v1/meta.json): build date, counts per kind, licence, the file list - [Feeds](https://nuclide.cc/feeds/changelog.xml): Atom feeds at /feeds/changelog.xml, /feeds/regulatory.xml, /feeds/calendar.xml, /feeds/pulse.xml and /newsletter/feed.xml; iCalendar at /catalysts/feed.ics - [Releases](https://github.com/casadesante/Nuclide/releases): the corpus attached to each tagged release as JSON, NDJSON, CSV and schema ## Kinds - [Indications](https://nuclide.cc/indications/): One page per disease a radiopharmaceutical is used to find or treat: state of the art, history, and what is coming. JSON at /api/v1/indications.json - [Isotopes](https://nuclide.cc/isotopes/): The radionuclides themselves: half-life, what they emit, how they are made and how tight supply is. JSON at /api/v1/isotopes.json - [Fronts](https://nuclide.cc/fronts/): The fronts of nuclear medicine: diagnostic imaging, theranostics, alpha therapy, isotope supply and dosimetry. JSON at /api/v1/fronts.json - [Technologies](https://nuclide.cc/technologies/): Every way a radionuclide is used to see or treat disease, explained. JSON at /api/v1/technologies.json - [Targets](https://nuclide.cc/targets/): The receptors, antigens and transporters tracers and therapies aim at. JSON at /api/v1/targets.json - [Drugs](https://nuclide.cc/drugs/): Approved and pipeline tracers and therapies, with what they target, which nuclide they carry and who makes them. JSON at /api/v1/drugs.json - [Companies](https://nuclide.cc/companies/): Who is building what. JSON at /api/v1/companies.json - [Institutions](https://nuclide.cc/institutions/): The centres and universities that matter, mapped and ranked. JSON at /api/v1/institutions.json - [Pathways](https://nuclide.cc/pathways/): The classic signalling circuits, drawn and explained. JSON at /api/v1/pathways.json - [Terms](https://nuclide.cc/terms/): Glossary with plain-English TL;DRs and Wikipedia links. JSON at /api/v1/terms.json - [Trials](https://nuclide.cc/trials/): Landmark and current trials that define the standard of care. JSON at /api/v1/trials.json - [Pairings](https://nuclide.cc/pairings/): Things that work better together, and things that do not. JSON at /api/v1/pairings.json - [Roadmaps](https://nuclide.cc/roadmaps/): Where a technology has been and where it is heading. JSON at /api/v1/roadmaps.json - [Ideas](https://nuclide.cc/ideas/): Hypotheses and new directions, linked to the evidence. JSON at /api/v1/ideas.json - [Collections](https://nuclide.cc/collections/): The open databases and registries the field runs on. JSON at /api/v1/collections.json - [People](https://nuclide.cc/people/): The clinicians and scientists doing the work: specialisms, bios, papers, and where to find them. JSON at /api/v1/people.json - [Bottlenecks](https://nuclide.cc/bottlenecks/): The systemic constraints slowing the field, from isotope supply to reimbursement, with the ideas that could break each one. JSON at /api/v1/bottlenecks.json - [Opportunities](https://nuclide.cc/opportunities/): Where a clinical decision cannot be made today and a radiopharmaceutical could settle it: the unmet need, the most advanced agent anywhere, the evidence on five domains and a traffic light on six. JSON at /api/v1/opportunities.json - [Key papers](https://nuclide.cc/key-papers/): The papers that changed practice or thinking, each explained: what it found, what it means, and what to be careful about. JSON at /api/v1/key papers.json - [Journals](https://nuclide.cc/journals/): Where the evidence is published: the journals, their scope and access model, and the key papers each one carried. JSON at /api/v1/journals.json ## Start here - [Opportunities](https://nuclide.cc/opportunities/): Where a clinical decision cannot be made today and a radiopharmaceutical might settle it, each with the evidence read and the study that would test it. - [The universe](https://nuclide.cc/universe/): Every approved product, trial, paper, congress abstract, patent and published unmet need in radiopharmaceuticals, cross-linked and searchable. - [Ideas from the data](https://nuclide.cc/universe/ideas/): Openings computed from the cross-links, each with the evidence behind it. - [Unmet needs](https://nuclide.cc/universe/gaps/): Quoted statements of unmet need from papers and congress abstracts, filterable by indication, target and theme. - [Explore](https://nuclide.cc/explore/): Pick an indication, switch kind, get a ranked and sortable list. - [Search](https://nuclide.cc/search/): Word and concept search side by side, each result explaining why it matched. - [Path finder](https://nuclide.cc/path/): How any two objects are related: shortest routes with every relationship named. - [Compare](https://nuclide.cc/compare/): Up to five agents, isotopes, targets, trials or indications side by side, differences highlighted. - [Landscape grid](https://nuclide.cc/pivot/): Count agents, trials or technologies by indication, target, isotope or company in one grid. - [Timeline](https://nuclide.cc/timeline/): Scrub through the years: approvals, trials and practice as it stood. - [Query](https://nuclide.cc/query/): Build a graph query and get a table. - [Graph explorer](https://nuclide.cc/graph/): Navigate the knowledge graph visually. - [Saved](https://nuclide.cc/saved/): Your saved table views and watched pages, with what changed since you looked. Stored in your browser only. ## Isotopes & agents - [Isotopes](https://nuclide.cc/isotopes/): Half-life, what it emits, how it is made, how tight supply is. - [Agents](https://nuclide.cc/drugs/): Therapeutic radiopharmaceuticals and diagnostic tracers, approved and in trials. - [Targets](https://nuclide.cc/targets/): PSMA, SSTR2, FAP and the rest: what the ligand is aimed at. - [Technologies](https://nuclide.cc/technologies/): Chelators, generators, production routes, scanners, dosimetry. - [Indications](https://nuclide.cc/indications/): What these agents are used for, in oncology, neurology, cardiology and infection. - [Fronts](https://nuclide.cc/fronts/): The areas of the field, from molecular imaging to alpha therapy and supply. - [Trials](https://nuclide.cc/trials/): Landmark and current trials, with results where they have reported. - [Pairings](https://nuclide.cc/pairings/): Theranostic pairs, combinations, sequences and the pairs to avoid. - [Roadmaps](https://nuclide.cc/roadmaps/): History to horizon for each part of the field. - [Dependency map](https://nuclide.cc/dependencies/): What each technology cannot exist without, drawn in layers. - [Molecule gallery](https://nuclide.cc/molecules/): Every agent with a 3D structure, filterable by modality, isotope and target. - [Bottlenecks](https://nuclide.cc/bottlenecks/): The constraints holding the field back, and the ideas that could break each one. - [Ideas](https://nuclide.cc/ideas/): Hypotheses and fixes, each with a proposed test. - [Glossary](https://nuclide.cc/terms/): Physics, chemistry, dosimetry, safety and regulation, in plain words. - [Collections](https://nuclide.cc/collections/): The open databases and standards the field runs on. - [Pathways](https://nuclide.cc/pathways/): The biology behind the targets, drawn and explained. ## News & evidence - [Isotope supply](https://nuclide.cc/supply/): Who makes Lu-177, Ac-225, Mo-99 and Pb-212, and how tight each is. - [Evidence](https://nuclide.cc/evidence/): Every trial ranked by evidence strength, endpoints as people out of 100. - [Trials in plain words](https://nuclide.cc/explained/): Every trial result as people out of 100, medians explained, surrogate endpoints flagged. - [Key papers](https://nuclide.cc/key-papers/): The papers that changed practice, each explained: what it found and what to be careful about. - [Journals](https://nuclide.cc/journals/): Where the evidence is published: scope, access model and the papers each venue carried. - [Readout calendar](https://nuclide.cc/calendar/): Decisions, readouts, advisory committees, congresses. - [Catalyst calendar](https://nuclide.cc/catalysts/): Regulatory decisions, expected readouts, filings and deal closings by company. - [Regulatory timeline](https://nuclide.cc/regulatory/): Every dated filing, approval, CRL and label change. - [Deals and licences](https://nuclide.cc/deals/): Who bought or licensed what, for how much. - [Failure museum](https://nuclide.cc/failures/): What did not work, and the lesson. - [Trial design picker](https://nuclide.cc/trial-designs/): Every trial design as a card: when to use it, a worked example and its main risk. - [Preprint tracker](https://nuclide.cc/preprints/): Recent preprints per target, agent and technology, and which have since been published. - [Publishing trends](https://nuclide.cc/papers/): Fastest-growing topics in the literature, refreshed weekly from Europe PMC. - [Research pulse](https://nuclide.cc/pulse/): What the leading journals, regulators and news sources are saying this month. - [Changelog](https://nuclide.cc/changelog/): What changed in Nuclide, and when. - [Data currency](https://nuclide.cc/status/): When each automated feed last ran, what is stale, and the incident log. - [Freshness](https://nuclide.cc/freshness/): How old is too old for each kind of record, and what is past due. - [Recent changes](https://nuclide.cc/history/): What changed on which record, field by field, from the git history. - [Audit](https://nuclide.cc/audit/): Staleness, contradictions and registry mismatches, recomputed each build. - [Corrections](https://nuclide.cc/corrections/): Every factual correction, what was wrong and how it was found. ## Institutions & people - [Institutions](https://nuclide.cc/institutions/): Theranostic centres, university hospitals, regulators and agencies, mapped. - [People](https://nuclide.cc/people/): The physicians, physicists and chemists doing the work. - [Companies](https://nuclide.cc/companies/): Radiopharma, isotope producers, generator and scanner makers. - [Trial leadership](https://nuclide.cc/leadership/): Who led the pivotal trials. - [Manufacturing map](https://nuclide.cc/manufacturing/): Where isotopes are produced and where agents are labelled and released. - [Trial sponsors](https://nuclide.cc/sponsors/): Who runs the most phase 2 and 3 trials, from the registry and the corpus. ## Learn & contribute - [About & methodology](https://nuclide.cc/about/): Rules for facts, ranking formulas, licence. - [Roadmap](https://nuclide.cc/roadmap/): Corpus health, every idea by status, and how Nuclide expands and stays current. - [Gaps to fill](https://nuclide.cc/gaps/): Objects and fields that need work. - [Review queue](https://nuclide.cc/review/): Which pages most need a named reviewer. - [Reviewer roster](https://nuclide.cc/reviewers/): Who has signed off pages, with declared conflicts of interest. - [Contributors](https://nuclide.cc/contributors/): Everyone who wrote or reviewed records, from the repository history. - [Weekly issue](https://nuclide.cc/newsletter/): What changed, regulatory events, upcoming readouts. No tracking. - [Suggest an edit](https://nuclide.cc/suggest/): Propose a correction; organisations can edit their own records. - [Open evaluation](https://nuclide.cc/eval/): Questions, a rubric and a public leaderboard. - [Data dictionary](https://nuclide.cc/schema/): Every kind, every field, its type and meaning, with a real example per kind. - [Build on Nuclide](https://nuclide.cc/build/): Recipes, OpenAPI spec, TypeScript types and the MCP server. - [Open API](https://nuclide.cc/api/): The corpus as JSON. - [Open data](https://nuclide.cc/data-sources/): Every open database Nuclide pulls from, with licences and cadence. - [Open tools](https://nuclide.cc/open-tools/): Open-source viewers, planners and pipelines you can use or build on. ## Optional - [About and methodology](https://nuclide.cc/about/): rules for facts, ranking formulas, licence - [Open API](https://nuclide.cc/api/): the corpus as JSON, with the endpoint list - [Build on Nuclide](https://nuclide.cc/build/): recipes, types, embeddable cards, the MCP server - [Corrections](https://nuclide.cc/corrections/): every factual correction and how it was found - [GitHub](https://github.com/casadesante/Nuclide): edit any record with a pull request