FAPI PET
FAPI PET is a PET scan that lights up the scaffolding around almost any solid tumour, including cancers the standard sugar scan misses.
Overview
Quinoline-based FAP inhibitors (FAPI-04, FAPI-46, FAPI-74) labelled with 68Ga or 18F image cancer-associated fibroblasts. Superior to FDG in pancreatic, gastric, HCC, and peritoneal disease in head-to-head series. Registrational trials for 68Ga-FAPI-46 and 18F-FAPI-74 (Sofie) are underway. Pairs with FAP-targeted radioligands.
- Detector ring
- FAP on fibroblasts
- 511 keV photon pair
How it works
Small molecule binds FAP on stromal fibroblasts; rapid uptake, low background, minimal brain and liver signal.
- Pan-cancer, high contrast
- No fasting needed
- Sees desmoplastic tumours FDG misses
- Also uptake in fibrosis, healing, arthritis
- Reports stroma not tumour cells
- Not yet approved
A FAP-targeted theranostic pair: one version images almost any solid tumour, the other treats it with radiation.
An experimental PET tracer that lights up the scaffolding cells cancers build around themselves, not the cancer cells directly. It is still being tested, not yet an approved medicine.
A drug that homes to the scaffolding cells tumours build around themselves, carrying a radioactive metal that fires alpha particles over a very short range. A matching scan version shows first whether a patient's tumour has the target.
Latest papers
topQuery for this technology: (TITLE:"FAPI PET" OR ABSTRACT:"FAPI PET" OR TITLE:"FAP inhibitor PET" OR ABSTRACT:"FAP inhibitor PET" OR TITLE:"68Ga-FAPI" OR ABSTRACT:"68Ga-FAPI" OR TITLE:"fibroblast activation protein PET" OR ABSTRACT:"fibroblast activation protein PET"). Results are unfiltered search hits about FAPI PET, not a curated reading list.
Similar pages
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