Rubidium Rb-82 chloride
A generator-produced radioactive form of the metal rubidium, chemically similar to potassium, given as a fast intravenous infusion; because it decays away in about a minute and a half it can be produced on site without a cyclotron, letting a PET scan of heart blood flow be done in around half an hour.
Overview
Rubidium Rb-82 chloride, marketed via the CardioGen-82 strontium-82/rubidium-82 generator, is a PET myocardial perfusion agent behaving like a potassium analogue with a first-pass extraction fraction of about 65% (and flow-dependent roll-off similar to or greater than the Tc-99m SPECT agents). Its ultra-short 75-second half-life is both its main practical advantage, no cyclotron is required since the generator is eluted with saline immediately before each dose, and its main constraint: imaging must begin within 60-130 seconds of infusion and the generator itself is regulated for strontium breakthrough.
The FDA label indicates it for PET imaging of the myocardium under rest or pharmacologic stress to evaluate regional myocardial perfusion in adults with suspected or existing coronary artery disease. Recommended adult dosing (Model 510 infusion system) is 1,480 MBq (40 mCi) per rest or stress component, with a range of 1,110-2,220 MBq, infused intravenously at 50 mL/min; a newer Model 1700 system doses by body weight (10-30 MBq/kg).
Rb-82 PET's speed (a full rest/stress study in about 30 minutes) and generator-based, cyclotron-free production have made it the most widely used PET perfusion tracer in the US for routine CAD work-up, and it is also used, alongside or instead of N-13 ammonia, as the resting perfusion half of the cardiac sarcoidosis PET protocol.
1.Rubidium Rb-82 chloride slips into a pocket on its target.
- Route
- Intravenous infusion (generator-eluted, produced immediately before use)
- Schedule
- 1,480 MBq (40 mCi) per rest or stress component, range 1,110-2,220 MBq, infused at 50 mL/min (Model 510); 10-30 MBq/kg on Model 1700; imaging starts 60-90 seconds after infusion, rest and stress separated by a minimum 10 minutes
Source: www.accessdata.fda.gov/drugsatfda_docs/label/2024/019414s034lbl.pdf. Doses are for orientation; the current label governs.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1989 | PET imaging of the myocardium under rest or pharmacologic stress to evaluate regional myocardial perfusion in adults with suspected or existing coronary artery disease |
Trials
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Latest papers
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