Medical cyclotrons, hot cells, and synthesis modules
The particle accelerators and shielded robotic chemistry boxes that make PET tracers in hospital basements and commercial pharmacies.
Overview
Compact 11-30 MeV cyclotrons from IBA (Cyclone), GE HealthCare (PETtrace, MINItrace), Siemens (Eclipse), ACSI (TR-24), and Sumitomo produce 18F, 68Ga, 64Cu, and 89Zr; shielded hot cells (Comecer, Von Gahlen, Tema Sinergie) house automated synthesis modules (Trasis AllinOne, IBA Synthera, GE FASTlab, Eckert & Ziegler Modular-Lab, Siemens Explora) that run GMP radiochemistry from cassettes. Solid-target 68Ga production is displacing generators at high-volume sites.
How it works
Proton bombardment of enriched targets produces the isotope; cassette-based automated modules perform labelling, purification, and formulation behind lead shielding with QC before release.
- On-site supply of short-lived isotopes
- Cassette chemistry standardises GMP production
- Capital and shielding cost ($2-5M per site)
- Skilled radiochemists scarce
- Site licensing takes years
Dependencies
Open the dependency map →Nothing recorded yet: a foundation, or a gap to fill.
Dependencies are what this technology cannot be delivered without: manufacturing steps, instruments, software, upstream methods. See its full chain on the map.
Latest papers
topQuery for this technology: (TITLE:"Medical cyclotrons, hot cells, and synthesis modules" OR ABSTRACT:"Medical cyclotrons, hot cells, and synthesis modules") AND (radiopharmaceutical OR radioligand OR radionuclide OR theranostic OR "nuclear medicine" OR "molecular imaging" OR radiotracer OR scintigraphy OR cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Medical cyclotrons, hot cells, and synthesis modules, not a curated reading list.
Similar pages
not linked directly; found by shared links- CompanyEckert & Ziegler
Shares Radionuclide generators and cold kits, Radiopharmacy and cyclotron networks, Cyclotron isotope production (F-18, Ga-68, Cu-64, Zr-89, At-211), Fluorine-18 and the tag supporting.
- CompanyPETNET Solutions (Siemens Healthineers)
Shares PET tracer manufacturing and distribution, Radiopharmacy and cyclotron networks, Cyclotron isotope production (F-18, Ga-68, Cu-64, Zr-89, At-211), Fluorine-18 and the tag supporting.
- CompanyJubilant Radiopharma
Shares PET tracer manufacturing and distribution, Radiopharmacy and cyclotron networks, Cyclotron isotope production (F-18, Ga-68, Cu-64, Zr-89, At-211) and the tag supporting.
- CompanyCardinal Health Nuclear & Precision Health Solutions
Shares PET tracer manufacturing and distribution, Radiopharmacy and cyclotron networks, Cyclotron isotope production (F-18, Ga-68, Cu-64, Zr-89, At-211) and the tag supporting.
- TechnologyNuclear medicine and total-body PET hardware
Shares Siemens Healthineers, GE HealthCare, PET (positron emission tomography), Radioligand therapy (beta emitters) and the tag supporting.
- CompanyCanon Medical Systems
Shares CT, MRI and PET scanner manufacturing and the tag supporting.
- CompanyMIM Software (GE HealthCare)
Shares Radioligand therapy (beta emitters) and the tag supporting.
- TechnologyTherapeutic isotope supply chain (Mo-99, Lu-177, Ac-225)
Shares Radiopharmacy and cyclotron networks, Radioligand therapy (beta emitters) and the tag supporting.