Folate receptor alpha
Folate receptor alpha is a vitamin receptor that ovarian cancer cells carry in large numbers, used as the docking site for the ADC mirvetuximab.
Overview
FRα is overexpressed in high-grade serous ovarian cancer, endometrial cancer, and lung adenocarcinoma. Mirvetuximab soravtansine (Elahere) is approved in FRα-high platinum-resistant ovarian cancer (MIRASOL). Next-generation FRα ADCs with topoisomerase-I payloads (ZW191, luveltamab tazevibulin, rinatabart sesutecan) target lower-expressing tumours.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · Folate receptor alpha is a vitamin receptor that ovarian cancer cells carry in large numbers, used as the docking site for the ADC mirvetuximab.
- 1 · What it is
Folate receptor alpha is a vitamin receptor that ovarian cancer cells carry in large numbers, used as the docking site for the ADC mirvetuximab.
- 2 · What goes wrong in cancer
GPI-anchored folate transporter; limited to apical surfaces in normal kidney, lung, and choroid plexus.
- 3 · How drugs use it
No product in this corpus aims at Folate receptor alpha yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
External identifiers
Companion diagnostics
- VENTANA FOLR1 (FOLR1-2.1) RxDx Assay · At least 75% of viable tumour cells with membrane staining of at least 2+ intensity (mirvetuximab soravtansine, ovarian cancer)
Biology
GPI-anchored folate transporter; limited to apical surfaces in normal kidney, lung, and choroid plexus.
- High-grade serous ovarian (~80% any expression)
- Endometrial
- NSCLC adenocarcinoma
- TNBC (subset)
Latest papers
topQuery for this target: (TITLE:"Folate receptor alpha" OR ABSTRACT:"Folate receptor alpha" OR TITLE:"FOLR1" OR ABSTRACT:"FOLR1") AND (radiopharmaceutical OR radioligand OR radionuclide OR theranostic OR "nuclear medicine" OR "molecular imaging" OR radiotracer OR scintigraphy OR cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Folate receptor alpha, not a curated reading list.
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