# Folate receptor alpha

Source: https://nuclide.cc/targets/folr1/  
Nuclide record `folr1` (Target). Data CC BY-NC 4.0, attribute "Data from Nuclide (nuclide.cc)"; commercial use needs a licence.

## TL;DR

Folate receptor alpha is a vitamin receptor that ovarian cancer cells carry in large numbers, used as the docking site for the ADC mirvetuximab.

## Summary

FRα is overexpressed in high-grade serous ovarian cancer, endometrial cancer, and lung adenocarcinoma. Mirvetuximab soravtansine (Elahere) is approved in FRα-high platinum-resistant ovarian cancer (MIRASOL). Next-generation FRα ADCs with topoisomerase-I payloads (ZW191, luveltamab tazevibulin, rinatabart sesutecan) target lower-expressing tumours.

## Fields

- Kind: Target
- Last checked: 2026-09-04
- Tags: adc-target
- Symbol: FOLR1
- Class: surface-antigen
- Biology: GPI-anchored folate transporter; limited to apical surfaces in normal kidney, lung, and choroid plexus.
- Where found: High-grade serous ovarian (~80% any expression); Endometrial; NSCLC adenocarcinoma; TNBC (subset)

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Folate_receptor_1
- Wikipedia: https://en.wikipedia.org/wiki/Folate_receptor_1

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JSON: https://nuclide.cc/api/v1/entities/folr1.json