CEACAM5
The classic 'CEA' tumour marker measured in blood, also present on the cell surface where ADCs can reach it.
Overview
CEACAM5 is carcinoembryonic antigen, a GPI-anchored adhesion molecule that is shed into circulation as the serum CEA marker and also sits on the cell surface where ADCs and T-cell engagers can reach it. It is overexpressed in colorectal (80-90% moderate-to-high by IHC), gastric (50-60%), lung adenocarcinoma, and pancreatic cancers; only 20-25% of non-squamous NSCLC met the high-expression threshold used in CARMEN. Tusamitamab ravtansine failed in phase 3 NSCLC (CARMEN-LC03), a setback that raised questions about payload choice and patient selection rather than the target itself. CEACAM5 remains pursued with T-cell engagers and next-generation ADCs. The simple version is the classic CEA blood marker, now also being used as a surface target for drug delivery.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · The classic 'CEA' tumour marker measured in blood, also present on the cell surface where ADCs can reach it.
- 1 · What it is
The classic 'CEA' tumour marker measured in blood, also present on the cell surface where ADCs can reach it.
- 2 · What goes wrong in cancer
GPI-anchored adhesion molecule; shed into circulation as the serum CEA marker.
- 3 · How drugs use it
No product in this corpus aims at CEACAM5 yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
External identifiers
Biology
GPI-anchored adhesion molecule; shed into circulation as the serum CEA marker.
- Colorectal
- Gastric
- Lung adenocarcinoma
- Pancreatic
Latest papers
topQuery for this target: (TITLE:"CEACAM5" OR ABSTRACT:"CEACAM5") AND (radiopharmaceutical OR radioligand OR radionuclide OR theranostic OR "nuclear medicine" OR "molecular imaging" OR radiotracer OR scintigraphy OR cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CEACAM5, not a curated reading list.
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