{"entity":{"id":"ceacam5","kind":"target","name":"CEACAM5","aka":[],"tldr":"The classic 'CEA' tumour marker measured in blood, also present on the cell surface where ADCs can reach it.","summary":"CEACAM5 is carcinoembryonic antigen, a GPI-anchored adhesion molecule that is shed into circulation as the serum CEA marker and also sits on the cell surface where ADCs and T-cell engagers can reach it. It is overexpressed in colorectal (80-90% moderate-to-high by IHC), gastric (50-60%), lung adenocarcinoma, and pancreatic cancers; only 20-25% of non-squamous NSCLC met the high-expression threshold used in CARMEN. Tusamitamab ravtansine failed in phase 3 NSCLC (CARMEN-LC03), a setback that raised questions about payload choice and patient selection rather than the target itself. CEACAM5 remains pursued with T-cell engagers and next-generation ADCs. The simple version is the classic CEA blood marker, now also being used as a surface target for drug delivery.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/Carcinoembryonic_antigen","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Carcinoembryonic_antigen"}],"tags":["adc-target","biomarker"],"related":[],"indications":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"symbol":"CEACAM5","hgnc":"HGNC:1817","ensembl":"ENSG00000105388","uniprot":"P06731","entrez":"1048","biology":"GPI-anchored adhesion molecule; shed into circulation as the serum CEA marker.","whereFound":["Colorectal","Gastric","Lung adenocarcinoma","Pancreatic"],"targetClass":"surface-antigen","prevalence":[]},"route":"/targets/ceacam5/","neighbours":{"pathway":[{"id":"lineage-plasticity-neuroendocrine","kind":"pathway","name":"Lineage plasticity & neuroendocrine transformation","route":"/pathways/lineage-plasticity-neuroendocrine/"}],"indication":[{"id":"colorectal-cancer","kind":"indication","name":"Colorectal cancer","route":"/indications/colorectal-cancer/"}],"opportunity":[{"id":"opp-ceacam5-imaging-colorectal","kind":"opportunity","name":"CEACAM5 imaging for occult colorectal recurrence","route":"/opportunities/opp-ceacam5-imaging-colorectal/"}],"idea":[{"id":"idea-pretargeted-alpha-therapy","kind":"idea","name":"Pretargeted alpha radioimmunotherapy","route":"/ideas/idea-pretargeted-alpha-therapy/"}],"target":[{"id":"tpbg-5t4","kind":"target","name":"5T4 (trophoblast glycoprotein)","route":"/targets/tpbg-5t4/"}]}}