Cabazitaxel
A second taxane that works after docetaxel and beat a second hormone pill head-to-head (CARD).
Overview
Cabazitaxel is a taxane with low affinity for the P-glycoprotein efflux pump, so it remains active in docetaxel-resistant disease. It is used in metastatic castration-resistant prostate cancer after docetaxel, with neutropenia as its main toxicity. TROPIC (2010) showed an overall survival benefit after docetaxel, and CARD (2019) showed it was superior to switching to a second androgen receptor pathway inhibitor in men who had already had one ARPI and docetaxel. It served as the comparator in TheraP, where it lost to 177Lu-PSMA-617 on PSA50 response (66% versus 37%) although overall survival was similar (HR 0.97), and in XALute against the T-cell engager xaluritamig. Its place relative to radioligands and T-cell engagers is therefore still being worked out. For a newcomer, it is the second taxane that works after docetaxel and beat a second hormone pill head-to-head.
1.Cabazitaxel slips into a pocket on its target.
- Medicare
- Part B (clinician-administered)
Given by infusion or injection in a clinic or hospital outpatient department, so it is a Part B drug: Medicare pays 80% after the Part B deductible and the patient owes 20% coinsurance, uncapped in Original Medicare unless a Medigap policy applies. Generics entered the US market between 2021 and 2024 after patent litigation.
- Commercial insurance
- covered with prior authorisation
Covered under the medical benefit with prior authorisation confirming diagnosis, biomarker status and line of therapy; site-of-care policies may steer infusions away from hospital outpatient departments. Plans typically require prior docetaxel.
- Assistance programmes
- Sanofi CareASSIST
- PAN Foundation: Disease-specific co-pay and premium funds; open and closed funds change monthly.
- HealthWell Foundation
- CancerCare Co-Payment Assistance Foundation
- Patient Advocate Foundation Co-Pay Relief
20% Part B coinsurance on a high-cost infusion adds up quickly: Medigap Plan G or N, Medicare Advantage maximum out-of-pocket, Medicaid dual eligibility, or a charity fund are the usual buffers.
Sources: Medicare.gov: Chemotherapy · Medicare.gov: Prescription drugs (outpatient, Part B). Not medical or financial advice; verify with your plan.
- Appraised for
- Metastatic hormone-relapsed prostate cancer after docetaxel
- NHS England
- Routinely funded for the appraised indication (or via managed access)
Sources: NICE TA391 · SMC advice: cabazitaxel. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.
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Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2010 | mCRPC after docetaxel |
Trials
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Landmark trials
Latest papers
topQuery for this drug: (TITLE:"Cabazitaxel" OR ABSTRACT:"Cabazitaxel" OR TITLE:"Jevtana" OR ABSTRACT:"Jevtana") AND (radiopharmaceutical OR radioligand OR radionuclide OR theranostic OR "nuclear medicine" OR "molecular imaging" OR radiotracer OR scintigraphy OR cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Cabazitaxel, not a curated reading list.
Similar pages
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Shares Metastatic castration-resistant prostate cancer, Prostate cancer, Lutetium-177.
- TrialA Phase 1/2 Study of 177Lu-NYM032 Injection in mCRPC
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- TermPSA50 / PSA90 response
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- TrialECLIPSE
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Shares Metastatic castration-resistant prostate cancer, Prostate cancer, Lutetium-177.
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