Technetium Tc-99m PSMA agents (PSMA-I&S)
A version of the PSMA prostate cancer scan that uses the same cheap, widely available radioactive tag as a standard bone scan instead of the PET tracers. Surgeons can also carry a small radiation detector into the operating room to help find and remove cancerous lymph nodes. It has not been through formal drug approval; it is used as an academic, in-house preparation.
Overview
99mTc-PSMA-I&S ([99mTc]Tc-mas3-y-nal-k(Sub-KuE)) was developed at the Technical University of Munich as a cost-effective, kit-based alternative to 111In-PSMA-I&T for PSMA-targeted radioguided surgery, first reported in the Journal of Nuclear Medicine in 2017. In that first-in-human report, preoperative SPECT/CT at 12 hours after injection showed high uptake in all lesions previously identified by 68Ga-PSMA-11 PET/MR, and a handheld gamma probe successfully guided intraoperative resection of metastatic lymph nodes down to 3 mm.
Beyond radioguided surgery, retrospective single-centre series have used PSMA-I&S SPECT/CT as a stand-alone diagnostic tool: one series reported patient-based sensitivity, specificity and accuracy of 86%, 100% and 92% for detecting primary prostate cancer, and for restaging in biochemical recurrence, sensitivity of 67% with specificity of 100%, generally trailing PSMA-PET's reported sensitivity in the low-PSA setting but offering same-day, low-cost imaging with equipment most nuclear medicine departments already own. Because it is produced from an academic cold-kit under local institutional protocols rather than an FDA- or EMA-reviewed marketing application, it has no formal regulatory approval or labelled dose; reported clinical activities have ranged from roughly 500-700 MBq for combined SPECT-and-surgery protocols.
- Gamma camera (rotates)
- Single photons (Tc-99m, Lu-177)
1.Technetium Tc-99m PSMA agents (PSMA-I&S) slips into a pocket on PSMA.
Trials
topTrials recruiting now
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Latest papers
topQuery for this drug: (TITLE:"Technetium Tc-99m PSMA agents" OR ABSTRACT:"Technetium Tc-99m PSMA agents" OR TITLE:"PSMA-I&S" OR ABSTRACT:"PSMA-I&S" OR TITLE:"99mTc-PSMA-I&S" OR ABSTRACT:"99mTc-PSMA-I&S" OR TITLE:"Tc-99m PSMA imaging and surgery" OR ABSTRACT:"Tc-99m PSMA imaging and surgery") AND (radiopharmaceutical OR radioligand OR radionuclide OR theranostic OR "nuclear medicine" OR "molecular imaging" OR radiotracer OR scintigraphy OR cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Technetium Tc-99m PSMA agents (PSMA-I&S), not a curated reading list.
Similar pages
not linked directly; found by shared links- AgentTechnetium Tc-99m medronate (MDP)
Shares SPECT/CT, SPECT & bone scan, Technetium-99m, Prostate cancer and the tag SPECT.
- IndicationSuspected upper urinary tract obstruction
Shares SPECT & bone scan, Technetium-99m and the tag SPECT.
- AgentGallium citrate Ga-67
Shares SPECT/CT, SPECT & bone scan and the tag SPECT.
- TrialBiodistribution and Dosimetry of Ga-68 P16-093 in Prostate Cancer
Shares Biochemical recurrence of prostate cancer, Gallium-68, Prostate cancer.
- IndicationFunctional assessment of thyroid nodules
Shares SPECT & bone scan, Technetium-99m and the tag SPECT.
- TargetCCK2 receptor (gastrin receptor)
Shares Indium-111, Technetium-99m, Gallium-68.
- IndicationPulmonary embolism: ventilation/perfusion imaging
Shares SPECT/CT, SPECT & bone scan, Technetium-99m and the tag SPECT.
- AgentTechnetium-99m exametazime (brain perfusion)
Shares SPECT & bone scan, Technetium-99m and the tag SPECT.