What changed: Hepatocellular carcinoma
Every dated change on the records linked to Hepatocellular carcinoma, newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.
September 2026 · 1
2026 · 1
2025 · 2
- 2025ApprovalYttrium-90 resin microspheresYttrium-90 resin microspheres approved in US
Local tumour control of unresectable hepatocellular carcinoma (no macrovascular invasion, Child-Pugh A, well-compensated liver function, good performance status)
- 2025MilestoneHepatocellular carcinomaCheckMate 9DW approval (nivolumab + ipilimumab); second FDA CRL for camrelizumab-rivoceranib
A milestone in how this cancer is treated.
2024 · 1
2023 · 2
- 2023GuidelineHepatocellular carcinomaGuideline AASLD 2023 / EASL 2025: Prevention
Universal HBV vaccination; antiviral suppression of HBV; direct-acting antiviral cure of HCV; alcohol and metabolic risk reduction. (NCCN Hepatobiliary Cancers)
- 2023GuidelineHepatocellular carcinomaGuideline AASLD 2023 Practice Guidance: Surveillance
Six-monthly ultrasound ± AFP in cirrhosis and high-risk HBV carriers; abbreviated MRI where ultrasound is inadequate.
October 2022 · 1
2022 · 1
2021 · 2
- 2021ApprovalDonafenibDonafenib approved in China
First-line unresectable hepatocellular carcinoma (ZGDH3)
- 2021ApprovalYttrium-90 glass microspheresYttrium-90 glass microspheres approved in US
Selective internal radiation therapy (SIRT) for local tumour control of solitary unresectable HCC (1-8 cm), Child-Pugh A cirrhosis, no macrovascular invasion, good performance status
2020 · 2
2019 · 1
2018 · 1
2017 · 2
2015 · 1
2014 · 1
November 2007 · 1
2007 · 3
2002 · 2
- 2002ApprovalYttrium-90 resin microspheresYttrium-90 resin microspheres approved in US
Unresectable metastatic liver tumours from primary colorectal cancer, with adjuvant intrahepatic artery chemotherapy (FUDR)
- 2002MilestoneHepatocellular carcinomaTACE proven to prolong survival (Llovet, Lo)
A milestone in how this cancer is treated.