# Nuclide record tpbg-5t4 (target). Data CC BY-NC 4.0, attribute "Data from Nuclide (nuclide.cc)". Whole corpus: https://nuclide.cc/api/v1/nuclide.nt
@prefix schema: <https://schema.org/> .
@prefix nuclide: <https://nuclide.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://nuclide.cc/targets/tpbg-5t4/>
  a schema:BioChemEntity ;
  nuclide:kind "target" ;
  schema:identifier "tpbg-5t4" ;
  schema:name "5T4 (trophoblast glycoprotein)"@en ;
  schema:alternateName "5T4"@en, "TPBG"@en, "5T4 oncofetal antigen"@en, "WAIF1"@en, "TPBG" ;
  schema:description "A protein the placenta makes during pregnancy that many cancers switch back on while most healthy adult tissue does not. Antibody-drug conjugates against it have been tested in patients, and since 2024 the first radiolabelled versions have reached people in China."@en ;
  schema:url <https://nuclide.cc/targets/tpbg-5t4/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12004>, <https://pubmed.ncbi.nlm.nih.gov/39377811/>, <https://pubmed.ncbi.nlm.nih.gov/41984171/>, <https://pubmed.ncbi.nlm.nih.gov/40443260/>, <https://pubmed.ncbi.nlm.nih.gov/28070718/>, <https://pubmed.ncbi.nlm.nih.gov/41832388/>, <https://clinicaltrials.gov/study/NCT06162988> ;
  nuclide:tag "oncofetal antigen", "antibody target", "ADC-validated", "China" ;
  nuclide:targetClass "surface-antigen" ;
  nuclide:related <https://nuclide.cc/technologies/immuno-pet/>, <https://nuclide.cc/isotopes/zr-89/>, <https://nuclide.cc/isotopes/lu-177/>, <https://nuclide.cc/isotopes/tb-161/>, <https://nuclide.cc/isotopes/ga-68/>, <https://nuclide.cc/technologies/radioligand-therapy/>, <https://nuclide.cc/targets/trop2/>, <https://nuclide.cc/targets/ceacam5/>, <https://nuclide.cc/targets/gpc3/>, <https://nuclide.cc/isotopes/f-18/> ;
  nuclide:indications <https://nuclide.cc/indications/colorectal-cancer/>, <https://nuclide.cc/indications/pancreatic-cancer/>, <https://nuclide.cc/indications/prostate-mcrpc/>, <https://nuclide.cc/indications/prostate-nepc/> .