# Nuclide record radium223-abiraterone-caution (pairing). Data CC BY-NC 4.0, attribute "Data from Nuclide (nuclide.cc)". Whole corpus: https://nuclide.cc/api/v1/nuclide.nt
@prefix schema: <https://schema.org/> .
@prefix nuclide: <https://nuclide.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://nuclide.cc/pairings/radium223-abiraterone-caution/>
  a schema:MedicalTherapy ;
  nuclide:kind "pairing" ;
  schema:identifier "radium223-abiraterone-caution" ;
  schema:name "Radium-223 with abiraterone: a caution, not a combination"@en ;
  schema:description "Giving the bone-targeting radiotherapy radium-223 together with the hormone drug abiraterone does not help patients live longer and roughly doubles or triples the risk of a broken bone compared with abiraterone alone. This combination is no longer recommended."@en ;
  schema:url <https://nuclide.cc/pairings/radium223-abiraterone-caution/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://dial.uclouvain.be/pr/boreal/object/boreal:213463/datastream/PDF_02/view>, <https://ascopost.com/issues/november-25-2018/treatment-with-radium-223-plus-abiraterone-not-advisable-in-metastatic-prostate-cancer/>, <https://pmc.ncbi.nlm.nih.gov/articles/PMC6642951/> ;
  nuclide:tag "prostate cancer", "safety signal", "fractures" ;
  nuclide:related <https://nuclide.cc/indications/prostate-mcrpc/>, <https://nuclide.cc/terms/bone-metastases/>, <https://nuclide.cc/people/chris-parker/>, <https://nuclide.cc/people/karim-fizazi/>, <https://nuclide.cc/terms/arpi/>, <https://nuclide.cc/isotopes/ra-223/> ;
  nuclide:pairs <https://nuclide.cc/drugs/radium-223/>, <https://nuclide.cc/drugs/abiraterone/> .