# Nuclide record radiohybrid-chemistry (technology). Data CC BY-NC 4.0, attribute "Data from Nuclide (nuclide.cc)". Whole corpus: https://nuclide.cc/api/v1/nuclide.nt
@prefix schema: <https://schema.org/> .
@prefix nuclide: <https://nuclide.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://nuclide.cc/technologies/radiohybrid-chemistry/>
  a schema:MedicalTherapy ;
  nuclide:kind "technology" ;
  schema:identifier "radiohybrid-chemistry" ;
  schema:name "Radiohybrid (rh) chemistry"@en ;
  schema:alternateName "rhPSMA"@en, "SiFA chemistry"@en, "silicon fluoride acceptor"@en ;
  schema:description "A radiohybrid molecule carries two possible attachment points, one for a fast PET-friendly radioactive fluorine tag and one for a radioactive metal used for treatment, so the imaging and treatment versions of the drug are chemically identical twins."@en ;
  schema:url <https://nuclide.cc/technologies/radiohybrid-chemistry/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://jnm.snmjournals.org/content/61/5/735>, <https://pmc.ncbi.nlm.nih.gov/articles/PMC7198388/>, <https://www.mdpi.com/1424-8247/14/7/701> ;
  nuclide:tag "chemistry", "PET", "PSMA" ;
  nuclide:related <https://nuclide.cc/technologies/dota-chelation/>, <https://nuclide.cc/technologies/psma-pet/>, <https://nuclide.cc/isotopes/f-18/>, <https://nuclide.cc/isotopes/ga-68/>, <https://nuclide.cc/isotopes/lu-177/>, <https://nuclide.cc/isotopes/ac-225/> ;
  nuclide:dependsOn <https://nuclide.cc/technologies/dota-chelation/>, <https://nuclide.cc/technologies/cyclotron-isotope-production/> .