# Nuclide record opp-alpha-synuclein-pet-parkinsons (opportunity). Data CC BY-NC 4.0, attribute "Data from Nuclide (nuclide.cc)". Whole corpus: https://nuclide.cc/api/v1/nuclide.nt
@prefix schema: <https://schema.org/> .
@prefix nuclide: <https://nuclide.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://nuclide.cc/opportunities/opp-alpha-synuclein-pet-parkinsons/>
  a schema:CreativeWork ;
  nuclide:kind "opportunity" ;
  schema:identifier "opp-alpha-synuclein-pet-parkinsons" ;
  schema:name "Alpha-synuclein PET: works for MSA, not for Parkinson's"@en ;
  schema:alternateName "a-synuclein PET"@en, "ACI-12589"@en ;
  schema:description "Parkinson's disease is defined by a protein clumping in the brain, and no scan can see it. The first tracer to reach patients does light up a rarer, related disease but not Parkinson's itself, while a spinal-fluid test already identifies Parkinson's with high accuracy."@en ;
  schema:url <https://nuclide.cc/opportunities/opp-alpha-synuclein-pet-parkinsons/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://pmc.ncbi.nlm.nih.gov/articles/PMC10611796/>, <https://www.alzforum.org/news/conference-coverage/first-field-synuclein-pet-only-multiple-system-atrophy>, <https://pmc.ncbi.nlm.nih.gov/articles/PMC13121216/>, <https://www.movementdisorders.org/MDS/Scientific-Issues/posts/The-past-present-and-future-roles-of-a-synuclein-seed-amplification-assays.htm>, <https://pmc.ncbi.nlm.nih.gov/articles/PMC12192484/> ;
  nuclide:tag "unmet need first", "neurology", "worked negative", "pharmacodynamic marker" ;
  nuclide:related <https://nuclide.cc/isotopes/f-18/>, <https://nuclide.cc/targets/tau-protein/>, <https://nuclide.cc/targets/amyloid-beta/> ;
  nuclide:indications <https://nuclide.cc/indications/parkinsonian-syndromes/> ;
  nuclide:technologies <https://nuclide.cc/technologies/pet/>, <https://nuclide.cc/technologies/pet-ct/> ;
  nuclide:targets <https://nuclide.cc/targets/alpha-synuclein/>, <https://nuclide.cc/targets/dopamine-transporter/> ;
  nuclide:drugs <https://nuclide.cc/drugs/i-123-ioflupane/> .