# Nuclide record lineage-plasticity-neuroendocrine (pathway). Data CC BY-NC 4.0, attribute "Data from Nuclide (nuclide.cc)". Whole corpus: https://nuclide.cc/api/v1/nuclide.nt
@prefix schema: <https://schema.org/> .
@prefix nuclide: <https://nuclide.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://nuclide.cc/pathways/lineage-plasticity-neuroendocrine/>
  a schema:BioChemEntity ;
  nuclide:kind "pathway" ;
  schema:identifier "lineage-plasticity-neuroendocrine" ;
  schema:name "Lineage plasticity & neuroendocrine transformation"@en ;
  schema:description "Under pressure from a drug that blocks its identity (the androgen receptor in prostate cancer, EGFR in lung cancer), a tumour can change what kind of cell it is, becoming a small-cell neuroendocrine cancer that no longer needs the blocked signal. It is the ultimate escape: not a new mutation in the engine, but a new engine."@en ;
  schema:url <https://nuclide.cc/pathways/lineage-plasticity-neuroendocrine/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Neuroendocrine_tumor> ;
  schema:citation <https://doi.org/10.1126/science.aah4199>, <https://doi.org/10.1038/nm.4045> ;
  nuclide:tag "mechanism", "mechanics-atlas" ;
  nuclide:indications <https://nuclide.cc/indications/prostate/>, <https://nuclide.cc/indications/sclc/> ;
  nuclide:targets <https://nuclide.cc/targets/dll3/>, <https://nuclide.cc/targets/b7h3/>, <https://nuclide.cc/targets/ceacam5/>, <https://nuclide.cc/targets/psma/> ;
  nuclide:drugs <https://nuclide.cc/drugs/enzalutamide/> .