# Nuclide record b-enriched-target-material (bottleneck). Data CC BY-NC 4.0, attribute "Data from Nuclide (nuclide.cc)". Whole corpus: https://nuclide.cc/api/v1/nuclide.nt
@prefix schema: <https://schema.org/> .
@prefix nuclide: <https://nuclide.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://nuclide.cc/bottlenecks/b-enriched-target-material/>
  a schema:Thing ;
  nuclide:kind "bottleneck" ;
  schema:identifier "b-enriched-target-material" ;
  schema:name "Enriched target material for therapeutic isotopes"@en ;
  schema:description "Making the pure form of lutetium-177 used in cancer drugs like Pluvicto requires starting from a rare, heavily purified metal called ytterbium-176. Almost all of the world's supply of that starting material has come from one country, which is a risky place for the whole medicine to depend on."@en ;
  schema:url <https://nuclide.cc/bottlenecks/b-enriched-target-material/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://pmc.ncbi.nlm.nih.gov/articles/PMC8241800/>, <https://www.problemgenome.com/briefs/health-yb176-enriched-isotope-single-country-supply>, <https://www.energy.gov/sites/default/files/2024-03/FY2025-PresidentsRequest-IRP.pdf> ;
  nuclide:tag "supply chain", "ytterbium-176", "lutetium-177", "enrichment" ;
  nuclide:related <https://nuclide.cc/ideas/idea-reg-yb176-enrichment-capacity/>, <https://nuclide.cc/bottlenecks/b-mo99-supply/>, <https://nuclide.cc/bottlenecks/b-ac225-supply/>, <https://nuclide.cc/isotopes/tc-99m/>, <https://nuclide.cc/isotopes/mo-99/>, <https://nuclide.cc/isotopes/lu-177/>, <https://nuclide.cc/isotopes/at-211/> ;
  nuclide:technologies <https://nuclide.cc/technologies/therapy-isotope-supply-chain/>, <https://nuclide.cc/technologies/research-reactor-isotope-production/>, <https://nuclide.cc/technologies/lu177-radioligand-therapy/> ;
  nuclide:drugs <https://nuclide.cc/drugs/pluvicto/>, <https://nuclide.cc/drugs/lutathera/>, <https://nuclide.cc/drugs/itm-11/> ;
  nuclide:companies <https://nuclide.cc/companies/novartis/>, <https://nuclide.cc/companies/itm/>, <https://nuclide.cc/companies/ntp-radioisotopes/>, <https://nuclide.cc/companies/curium/> .