# Nuclide record b-ac225-supply (bottleneck). Data CC BY-NC 4.0, attribute "Data from Nuclide (nuclide.cc)". Whole corpus: https://nuclide.cc/api/v1/nuclide.nt
@prefix schema: <https://schema.org/> .
@prefix nuclide: <https://nuclide.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://nuclide.cc/bottlenecks/b-ac225-supply/>
  a schema:Thing ;
  nuclide:kind "bottleneck" ;
  schema:identifier "b-ac225-supply" ;
  schema:name "Actinium-225 supply"@en ;
  schema:description "There is barely enough of the radioactive metal actinium-225 in the world to treat a few hundred patients a year, even though several new cancer drugs need it. New ways of making it are being built, but they are not yet running at full scale."@en ;
  schema:url <https://nuclide.cc/bottlenecks/b-ac225-supply/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://pmc.ncbi.nlm.nih.gov/articles/PMC12468084/>, <https://www.fiercepharma.com/pharma/bms-and-rayzebio-halt-radiotherapy-trial-enrollment-after-isotope-runs-scarce>, <https://www.energy.gov/science/ip/isotope-rd-and-production-doe-ip>, <https://synapse.patsnap.com/article/pantera-secures-E282AC134m-to-boost-actinium-225-production> ;
  nuclide:tag "alpha emitter", "supply chain", "actinium-225" ;
  nuclide:related <https://nuclide.cc/ideas/idea-reg-legacy-radium-recovery-ac225/>, <https://nuclide.cc/ideas/idea-reg-alpha-emitter-portfolio/>, <https://nuclide.cc/ideas/idea-reg-ac225-accelerator-pharmacopoeia/>, <https://nuclide.cc/ideas/idea-reg-isotope-supply-observatory/>, <https://nuclide.cc/bottlenecks/b-rlt-trial-capacity/>, <https://nuclide.cc/bottlenecks/b-manufacturing-cell-therapy/>, <https://nuclide.cc/isotopes/ac-225/> ;
  nuclide:technologies <https://nuclide.cc/technologies/actinium-225-supply/>, <https://nuclide.cc/technologies/targeted-alpha-therapy/>, <https://nuclide.cc/technologies/cyclotron-isotope-production/>, <https://nuclide.cc/technologies/therapy-isotope-supply-chain/> ;
  nuclide:drugs <https://nuclide.cc/drugs/ac225-psma/>, <https://nuclide.cc/drugs/ryz101/> ;
  nuclide:companies <https://nuclide.cc/companies/rayzebio/>, <https://nuclide.cc/companies/bms/>, <https://nuclide.cc/companies/actinium-pharmaceuticals/>, <https://nuclide.cc/companies/terrapower-isotopes/>, <https://nuclide.cc/companies/orano-med/>, <https://nuclide.cc/companies/northstar-medical-radioisotopes/>, <https://nuclide.cc/companies/bayer/> ;
  nuclide:trials <https://nuclide.cc/trials/action-1/> .