# Nuclide record astra (trial). Data CC BY-NC 4.0, attribute "Data from Nuclide (nuclide.cc)". Whole corpus: https://nuclide.cc/api/v1/nuclide.nt
@prefix schema: <https://schema.org/> .
@prefix nuclide: <https://nuclide.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://nuclide.cc/trials/astra/>
  a schema:MedicalTrial ;
  nuclide:kind "trial" ;
  schema:identifier "astra", "NCT01843062" ;
  schema:name "ASTRA"@en ;
  schema:description "Adding a MEK inhibitor to boost iodine uptake before ablation did not improve complete remission rates, cooling the 'redifferentiation for everyone' idea."@en ;
  schema:url <https://nuclide.cc/trials/astra/> ;
  schema:dateModified "2026-09-27"^^xsd:date ;
  schema:citation <https://doi.org/10.1200/JCO.21.00714>, <https://clinicaltrials.gov/study/NCT01843062>, <https://ascopubs.org/doi/10.1200/JCO.21.00714> ;
  nuclide:status "negative" ;
  nuclide:tag "failure", "lesson:adjuvant-vs-active-disease" ;
  nuclide:phase "3" ;
  nuclide:indications <https://nuclide.cc/indications/thyroid/> ;
  nuclide:technologies <https://nuclide.cc/technologies/radioiodine-therapy/> .