{"entity":{"id":"radioligand-therapy","kind":"technology","name":"Radioligand therapy (beta emitters)","aka":[],"tldr":"A drug that finds tumour cells and carries a radioactive atom that irradiates them from inside the body.","summary":"177Lu-DOTATATE (Lutathera, 2018) in neuroendocrine tumours and 177Lu-PSMA-617 (Pluvicto, 2022; pre-chemotherapy label 2025; 2026 label expansion) in prostate cancer are the approved beta-emitter therapies. Pipeline: 177Lu-FAP, 177Lu-PSMA-I&T, 177Lu-NeoB (GRPR), 177Lu-labelled antibodies. Dosimetry-guided personalised dosing is emerging.","status":"approved","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/Radioligand_therapy","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Radioligand_therapy"}],"tags":[],"related":["lu-177"],"indications":["prostate","neuroendocrine"],"sections":[],"technologies":["psma-pet","spect","targeted-alpha-therapy"],"targets":["psma","sstr2","fap"],"drugs":["pluvicto","lutathera"],"companies":["clarity-pharmaceuticals","abdera-therapeutics","alpha-9-oncology","ariceum-therapeutics","artbio","atomic-alchemy","evergreen-theragnostics","mariana-oncology","nucleus-radiopharma","point-biopharma","precirix","radionetics-oncology","ratio-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["cancer-biotherapy-and-radiopharmaceuticals"],"dependsOn":["therapy-isotope-supply-chain","radiopharmacy-network","medical-cyclotrons-synthesis-modules","pet-ct","radioligand-dosimetry"],"notes":[],"principle":"177Lu emits beta particles with ~2 mm range and gamma photons for SPECT imaging; the ligand determines biodistribution.","strengths":["Systemic, whole-body targeting of microscopic disease","Crossfire kills antigen-negative neighbours","Imaging companion selects patients"],"limitations":["Marrow and kidney dose","Isotope logistics (6.7-day half-life)","Not curative alone"],"since":2018},"route":"/technologies/radioligand-therapy/","neighbours":{"isotope":[{"id":"lu-177","kind":"isotope","name":"Lutetium-177","route":"/isotopes/lu-177/"}],"indication":[{"id":"grade-3-net","kind":"indication","name":"Grade 3 well-differentiated neuroendocrine tumour","route":"/indications/grade-3-net/"},{"id":"hcc","kind":"indication","name":"Hepatocellular carcinoma","route":"/indications/hcc/"},{"id":"hereditary-ppgl","kind":"indication","name":"Hereditary pheochromocytoma and paraganglioma (SDHx, VHL, RET, NF1, MAX and 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