{"entity":{"id":"lantheus","kind":"company","name":"Lantheus","aka":["Progenics Pharmaceuticals, Inc.","Progenics","Molecular Insight Pharmaceuticals, Inc.","Molecular Insight Pharmaceuticals"],"tldr":"Lantheus makes Pylarify, the leading PSMA PET agent, with a new TruVu formulation approved in March 2026.","summary":"Lantheus, based in Bedford, Massachusetts, and listed as LNTH, makes Pylarify, or piflufolastat F-18, the leading PSMA PET agent, with a new TruVu formulation approved in March 2026. Its portfolio also includes Neuraceq for amyloid imaging, PNT2002, a 177Lu-PSMA-I&T therapy whose SPLASH phase 3 missed overall survival, and PNT2003, a generic 177Lu-DOTATATE, and Nuclide also links it to iobenguane I-131 and samarium-153 lexidronam. It connects to prostate cancer, to PET tracer manufacturing and distribution and radionuclide generators, and to Evergreen Theragnostics. Whether an imaging leader can become a therapy company after SPLASH is the open question. Piflufolastat F-18 has its own page.","asOf":"2026-09-04","links":[{"label":"Official website","url":"https://www.lantheus.com"}],"tags":[],"related":["f-18","lu-177","i-131","sm-153"],"indications":[],"sections":[],"technologies":[],"targets":[],"drugs":["pylarify","i131-mibg"],"companies":["evergreen-theragnostics"],"institutions":[],"pathways":[],"terms":[],"trials":["nct06298916","nct07357519"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hq":"Bedford, MA","country":"US","companyType":"radiopharma","website":"https://www.lantheus.com","ticker":"LNTH","investors":[],"funding":[]},"route":"/companies/lantheus/","neighbours":{"isotope":[{"id":"f-18","kind":"isotope","name":"Fluorine-18","route":"/isotopes/f-18/"},{"id":"i-131","kind":"isotope","name":"Iodine-131","route":"/isotopes/i-131/"},{"id":"lu-177","kind":"isotope","name":"Lutetium-177","route":"/isotopes/lu-177/"},{"id":"sm-153","kind":"isotope","name":"Samarium-153","route":"/isotopes/sm-153/"},{"id":"tc-99m","kind":"isotope","name":"Technetium-99m","route":"/isotopes/tc-99m/"}],"drug":[{"id":"i131-mibg","kind":"drug","name":"131I-MIBG (iobenguane I-131) therapy","route":"/drugs/i131-mibg/"},{"id":"lu177-psma-it","kind":"drug","name":"177Lu-PSMA-I&T","route":"/drugs/lu177-psma-it/"},{"id":"f-18-florbetaben","kind":"drug","name":"Florbetaben F-18","route":"/drugs/f-18-florbetaben/"},{"id":"f-18-florquinitau","kind":"drug","name":"Florquinitau F-18","route":"/drugs/f-18-florquinitau/"},{"id":"iobenguane-i-131","kind":"drug","name":"Iobenguane I-131 (therapeutic)","route":"/drugs/iobenguane-i-131/"},{"id":"lu-177-pnt2002","kind":"drug","name":"Lutetium-177 PNT2002","route":"/drugs/lu-177-pnt2002/"},{"id":"pylarify","kind":"drug","name":"Piflufolastat F-18 / Pylarify TruVu","route":"/drugs/pylarify/"},{"id":"samarium-153-lexidronam","kind":"drug","name":"Samarium-153 lexidronam","route":"/drugs/samarium-153-lexidronam/"}],"company":[{"id":"evergreen-theragnostics","kind":"company","name":"Evergreen Theragnostics","route":"/companies/evergreen-theragnostics/"},{"id":"life-molecular-imaging","kind":"company","name":"Life Molecular Imaging","route":"/companies/life-molecular-imaging/"}],"trial":[{"id":"nct06298916","kind":"trial","name":"64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer","route":"/trials/nct06298916/"},{"id":"nct07357519","kind":"trial","name":"Lu-TARGO (177Lu-TARGeted Osteosarcoma Therapy)","route":"/trials/nct07357519/"}],"indication":[{"id":"prostate","kind":"indication","name":"Prostate cancer","route":"/indications/prostate/"}],"technology":[{"id":"cyclotron-isotope-production","kind":"technology","name":"Cyclotron isotope production (F-18, Ga-68, Cu-64, Zr-89, At-211)","route":"/technologies/cyclotron-isotope-production/"},{"id":"pet-tracer-manufacturing","kind":"technology","name":"PET tracer manufacturing and distribution","route":"/technologies/pet-tracer-manufacturing/"},{"id":"radionuclide-generators-kits","kind":"technology","name":"Radionuclide generators and cold kits","route":"/technologies/radionuclide-generators-kits/"},{"id":"radiopharmaceutical-gmp-release","kind":"technology","name":"Radiopharmaceutical GMP and releasing a drug that decays","route":"/technologies/radiopharmaceutical-gmp-release/"}],"bottleneck":[{"id":"b-reimbursement-coding","kind":"bottleneck","name":"Reimbursement and coding for radiopharmaceuticals","route":"/bottlenecks/b-reimbursement-coding/"}],"section":[{"id":"f-cardiac-imaging","kind":"section","name":"Cardiac imaging","route":"/fronts/f-cardiac-imaging/"},{"id":"f-molecular-imaging","kind":"section","name":"Molecular imaging","route":"/fronts/f-molecular-imaging/"},{"id":"f-radioligand-therapy","kind":"section","name":"Radioligand therapy","route":"/fronts/f-radioligand-therapy/"}]}}