{"entity":{"id":"delphine-chen","kind":"person","name":"Delphine L. Chen","aka":[],"tldr":"A Seattle-based nuclear medicine physician-scientist who ran the first human trial of a PET tracer that shows whether a tumour will respond to PARP-inhibitor drugs, and who now directs nuclear medicine and molecular imaging therapy at the Fred Hutchinson Cancer Center.","summary":"Delphine Chen holds the Wil B. Nelp, MD Endowed Professorship in Nuclear Medicine at the University of Washington and directs Molecular Imaging and Therapy at Fred Hutchinson Cancer Center, a role she has held since 2019; from January 2026 she also became Clinical Research Director for Radiology at Fred Hutch. She was principal investigator on the first-in-human trial of 18F-fluorthanatrace (18F-FTT), a PET tracer for imaging PARP-1 expression to help predict response to PARP-inhibitor drugs, developed with a patent held by Washington University.\n\nHer clinical practice covers the full range of oncologic PET and nuclear medicine therapies, and she has led trials using 68Ga-PSMA-11 PET to predict prostate cancer response to standard therapies. She currently serves SNMMI as President of the Center for Molecular Imaging, Innovation, and Translation.","asOf":"2026-09-22","links":[{"label":"Fred Hutch faculty profile","url":"https://www.fredhutch.org/en/faculty-lab-directory/chen-delphine.html"},{"label":"UW Radiology profile","url":"https://rad.uw.edu/people/dlchen7"}],"tags":["PARP PET","clinician-scientist"],"related":["parp-pet","parp","snmmi","f-18","ga-68"],"indications":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Professor, Clinical Research Division, Fred Hutchinson Cancer Center; Professor of Radiology, University of Washington; Clinical Research Director for Radiology, Fred Hutch (from January 2026; Director of Molecular Imaging and Therapy, Fred Hutch, since 2019)","specialisms":["PARP PET imaging","PET methods development","radioligand therapy multidisciplinary care"],"profiles":[{"label":"Fred Hutch faculty profile","url":"https://www.fredhutch.org/en/faculty-lab-directory/chen-delphine.html"},{"label":"UW Radiology profile","url":"https://rad.uw.edu/people/dlchen7"}],"papers":[{"title":"PET Imaging of PARP Expression Using 18F-Olaparib","journal":"Journal of Nuclear Medicine","year":2019,"doi":"10.2967/jnumed.118.219733"},{"title":"A PET Radiotracer for Imaging Poly (ADP-Ribose) Polymerase-1","journal":"Radiology","year":2022,"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8830434/"},{"title":"Pilot study: PARP1 imaging in advanced prostate cancer","journal":"Molecular Imaging and Biology","year":2022,"url":"https://digitalcommons.wustl.edu/oa_4/3816"}]},"route":"/people/delphine-chen/","neighbours":{"technology":[{"id":"parp-pet","kind":"technology","name":"PARP PET","route":"/technologies/parp-pet/"}],"target":[{"id":"parp","kind":"target","name":"PARP","route":"/targets/parp/"}],"institution":[{"id":"snmmi","kind":"institution","name":"Society of Nuclear Medicine and Molecular Imaging","route":"/institutions/snmmi/"}],"isotope":[{"id":"f-18","kind":"isotope","name":"Fluorine-18","route":"/isotopes/f-18/"},{"id":"ga-68","kind":"isotope","name":"Gallium-68","route":"/isotopes/ga-68/"}]}}