{"entity":{"id":"cytopenias","kind":"term","name":"Cytopenias and myelosuppression","aka":["cytopenia","cytopenias","myelosuppression","myelosuppressive","bone marrow suppression","marrow suppression","marrow toxicity","haematological toxicity","hematological toxicity","haematologic toxicity","hematologic toxicity","pancytopenia","bicytopenia","lymphopenia","lymphocytopenia","prolonged cytopenias","late cytopenias","ICAHT","immune effector cell-associated haematotoxicity","count recovery","blood counts","full blood count","complete blood count","CBC"],"tldr":"The umbrella term for low blood counts of any kind (white cells, red cells, platelets) when treatment suppresses the bone marrow. Most chemotherapy causes it temporarily; radioligands, CAR-T and some pills cause longer-lasting versions.","summary":"Myelosuppression is the shared toxicity of cytotoxic chemotherapy, conditioning regimens, lymphodepletion, radioligand therapy (177Lu-PSMA, PRRT) and a range of targeted agents, graded per lineage by CTCAE; pancytopenia means all three lineages are low. Blood counts before each cycle gate treatment, and delays and dose reductions are the standard responses. After CAR-T, prolonged and biphasic cytopenias (ICAHT) affect a third of patients and drive infection deaths months after infusion; lymphopenia is a marker of poorer immunotherapy outcomes. Therapy-related MDS is the late, permanent form of marrow injury.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Myelosuppression","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Myelosuppression"}],"tags":[],"related":["thrombocytopenia","anaemia","lu-177"],"indications":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Side effects"},"route":"/terms/cytopenias/","neighbours":{"term":[{"id":"anaemia","kind":"term","name":"Anaemia","route":"/terms/anaemia/"},{"id":"myelosuppression-after-rlt","kind":"term","name":"Myelosuppression after radioligand therapy","route":"/terms/myelosuppression-after-rlt/"},{"id":"renal-protection-amino-acids","kind":"term","name":"Renal protection with amino acid co-infusion","route":"/terms/renal-protection-amino-acids/"},{"id":"thrombocytopenia","kind":"term","name":"Thrombocytopenia","route":"/terms/thrombocytopenia/"}],"isotope":[{"id":"lu-177","kind":"isotope","name":"Lutetium-177","route":"/isotopes/lu-177/"}]}}