# TROP2 PET

Source: https://nuclide.cc/technologies/trop2-pet/  
Nuclide record `trop2-pet` (Technology). Data CC BY-NC 4.0, attribute "Data from Nuclide (nuclide.cc)"; commercial use needs a licence.

## TL;DR

An experimental PET scan that shows whether a tumour carries the TROP2 protein, so doctors could pick the right ADC before giving it.

## Summary

89Zr-labelled anti-TROP2 antibodies and 68Ga/18F-labelled TROP2 nanobodies and peptides (Fudan University, Peking Union, others) have been imaged in first-in-human studies in breast, lung, and pancreatic cancer. The goal is non-invasive, whole-body, heterogeneity-aware selection and monitoring for sacituzumab govitecan, datopotamab deruxtecan, and sacituzumab tirumotecan, where IHC has been an unreliable predictor.

## Fields

- Kind: Technology
- Status: phase-1
- Last checked: 2026-09-04
- Tags: frontier
- Principle: A radiolabelled TROP2 binder is imaged; antibody tracers image at 3-6 days with 89Zr, nanobodies within 1-2 hours with 68Ga/18F.
- Since: 2023
- Strengths: Whole-body target map; Could resolve intratumoural heterogeneity; Repeatable on progression
- Limitations: Early stage; no validated SUV cut-off; Antibody tracers are slow; nanobodies have renal uptake; Unclear whether expression level predicts ADC response

## Connected records

- isotopes: [Fluorine-18](https://nuclide.cc/isotopes/f-18/), [Gallium-68](https://nuclide.cc/isotopes/ga-68/), [Zirconium-89](https://nuclide.cc/isotopes/zr-89/)
- technologies: [Immuno-PET](https://nuclide.cc/technologies/immuno-pet/), [PET (positron emission tomography)](https://nuclide.cc/technologies/pet/)
- targets: [TROP2](https://nuclide.cc/targets/trop2/)
- institutions: [Fudan University Shanghai Cancer Center](https://nuclide.cc/institutions/fuscc/)
- roadmaps: [Molecular imaging roadmap: FDG → PSMA → FAP → antigen and immune PET](https://nuclide.cc/roadmaps/molecular-imaging-roadmap/)
- ideas: [Alpha radioligands after ADC failure](https://nuclide.cc/ideas/idea-alpha-after-adc/), [TROP2 PET to choose and sequence TROP2 ADCs](https://nuclide.cc/ideas/idea-trop2-pet-selection/)
- people: [Shaoli Song](https://nuclide.cc/people/song-shaoli/)
- indications: [Triple-negative breast cancer](https://nuclide.cc/indications/breast-triple-negative/)
- opportunities: [TROP2 imaging where no tissue test is required](https://nuclide.cc/opportunities/opp-trop2-imaging-heterogeneity/)
- fronts: [Molecular imaging](https://nuclide.cc/fronts/f-molecular-imaging/)

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