# Nectin-4

Source: https://nuclide.cc/targets/nectin4/  
Nuclide record `nectin4` (Target). Data CC BY-NC 4.0, attribute "Data from Nuclide (nuclide.cc)"; commercial use needs a licence.

## TL;DR

Nectin-4 is an adhesion protein plentiful on bladder cancer cells, used as the docking site for the ADC enfortumab vedotin.

## Summary

Nectin-4 is expressed at high levels in urothelial carcinoma and also in breast, lung, and pancreatic cancers. Enfortumab vedotin plus pembrolizumab is first-line standard in advanced urothelial cancer (EV-302). Next-generation Nectin-4 ADCs with topoisomerase-I payloads (MK-3120) and Nectin-4×TROP2 bispecific ADCs (AK146D1, AVZO-103) are in development.

## Fields

- Kind: Target
- Last checked: 2026-09-04
- Tags: adc-target
- Symbol: NECTIN4
- Class: surface-antigen
- Biology: Nectin-4 is a cell adhesion molecule and also a receptor for measles virus. Skin expression explains the rash seen with enfortumab.
- Where found: Urothelial carcinoma (>80%); TNBC; NSCLC; Pancreatic

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Nectin-4
- Wikipedia: https://en.wikipedia.org/wiki/Nectin-4

## Connected records

- technologies: [Peptide-drug & small-molecule-drug conjugates](https://nuclide.cc/technologies/peptide-drug-conjugate/)
- companies: [Aktis Oncology](https://nuclide.cc/companies/aktis-oncology/)
- indications: [Urothelial cancer](https://nuclide.cc/indications/urothelial-cancer/)
- opportunities: [A liver-cleared Nectin-4 tracer for urothelial cancer](https://nuclide.cc/opportunities/opp-nectin4-imaging-urothelial/)

---
JSON: https://nuclide.cc/api/v1/entities/nectin4.json